Substance 3D Painter 12.1
Continuous rebaking, skew-correction painting, and OpenPBR by default.
Painter 12.1 goes after the bake-tweak-rebake loop: baking now updates continuously as you change parameters, with no manual re-trigger. Skew-correction painting fixes normal-map projection errors, and a new hard-surface unwrap mode targets mechanical models. The quieter but bigger shift is Painter switching its default shading model to the open OpenPBR standard, off Adobe's proprietary one, which means materials port more predictably across renderers and engines. Test your export presets after upgrading; a default shading-model change is the kind of thing that surfaces in the engine, not the viewport.
Substance 3D Painter
Best for teams who want AAA-grade texturing with one-click export to any engine.